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Updated: Jul 14, 2025
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
[Research progress in tigliane-type macrocyclic diterpenoids]
Hong-Hu Tan1, Meng Xia2, Ping Su2
1State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China School of Pharmacy, Nanjing University of Chinese Medicine Nanjing 210023, China.
This review summarizes 115 novel tigliane diterpenoids discovered since 2013, highlighting their unique structures and potent antiviral and cytotoxic activities. These compounds show promise for developing new anti-AIDS, anti-tuberculosis, and anti-tumor drugs.
Area of Science:
- Natural Products Chemistry
- Medicinal Chemistry
- Pharmacology
Background:
- Tigliane diterpenoids, sourced from Euphorbiaceae and Thymelaeaceae plants, possess complex structures and significant bioactivities.
- These compounds are classified based on functional groups, including phorbol esters and their derivatives.
- They exhibit notable antiviral and cytotoxic properties, suggesting therapeutic potential.
Conclusions:
- Tigliane diterpenoids represent a promising class of natural products for drug discovery.
- Their diverse structures and bioactivities offer potential for anti-AIDS, anti-tuberculosis, and anti-cancer therapies.
- Further research into these compounds could yield novel clinical drug candidates.
