Primary intracranial lymphomas-incidence and survival: a population-based study

Area of Science:

• Neuro-oncology
• Epidemiology
• Surgical Oncology

Background:

• Primary intracranial lymphoma (PICL) diagnosis often requires biopsy, yet the impact of tumor resection remains debated.
• Understanding PICL epidemiology and surgical outcomes is crucial for improving patient prognosis.

Purpose of the Study:

• To investigate the epidemiology of primary intracranial lymphoma in the USA.
• To evaluate the relationship between surgical resection and patient survival in primary intracranial lymphoma.

Main Methods:

• Retrospective analysis of the SEER database for primary intracranial lymphoma incidence and demographics.
• Kaplan-Meier analysis and multivariate Cox proportional hazards models to assess surgical impact and prognostic indicators.

Main Results:

• Incidence of primary intracranial lymphoma increases with age, is highest in non-Hispanic Asian/Pacific Islander populations, and is more prevalent in males.
• Total tumor resection significantly improved both overall and cancer-specific survival for primary intracranial lymphoma patients.
• Favorable prognostic factors include younger age (<60), diagnosis after 2010, supratentorial location, and female sex. Diffuse large B-cell lymphoma subtype indicated poorer survival.

Conclusions:

• Surgical resection, especially complete removal, is associated with significantly better survival outcomes for primary intracranial lymphoma.
• Epidemiological data reveal distinct demographic patterns and risk factors for primary intracranial lymphoma.
• Findings provide valuable insights for clinicians and patients regarding primary intracranial lymphoma management and prognosis.