Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Human Visual Claustrum Responses to Physical Stimulus Properties and Subjective Content During Movie Viewing.

Human brain mapping·2026
Same author

Objective quality assessment for precision functional MRI data.

Neuron·2026
Same author

How Standardized Is Transcranial Magnetic Stimulation Treatment for Depression? Large-Cohort Modeling Reveals Systematic Dosimetric Variability.

Psychotherapy and psychosomatics·2026
Same author

Robust and reproducible population receptive field mapping in patients with retinal pathologies.

Eye (London, England)·2026
Same author

An exploratory study of glycemic biomarkers and rTMS treatment outcomes in treatment-resistant depression.

BMC psychiatry·2026
Same author

Objective Quality Assessment for Precision Functional MRI Data.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Jul 14, 2025

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
07:12

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

3.6K

Concurrent TMS/fMRI reveals individual DLPFC dose-response pattern.

Martin Tik1, Maria Vasileiadi2, Michael Woletz2

  • 1MR Center of Excellence, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Lazarettgasse 14, Vienna 1090, Austria; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA.

Neuroimage
|October 7, 2023
PubMed
Summary
This summary is machine-generated.

Investigating transcranial magnetic stimulation (TMS) dose-response in the dorsolateral prefrontal cortex (DLPFC) revealed significant individual variability. Concurrent TMS/fMRI may optimize treatment by personalizing stimulation intensity for conditions like depression.

Keywords:
Dose responseExcitabilityTMS-fMRIThresholdTranscranial magnetic stimulation

More Related Videos

Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex
07:42

Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex

Published on: August 17, 2018

11.8K
A Protocol for the Administration of Real-Time fMRI Neurofeedback Training
07:05

A Protocol for the Administration of Real-Time fMRI Neurofeedback Training

Published on: August 24, 2017

11.1K

Related Experiment Videos

Last Updated: Jul 14, 2025

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
07:12

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

3.6K
Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex
07:42

Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex

Published on: August 17, 2018

11.8K
A Protocol for the Administration of Real-Time fMRI Neurofeedback Training
07:05

A Protocol for the Administration of Real-Time fMRI Neurofeedback Training

Published on: August 24, 2017

11.1K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Transcranial magnetic stimulation (TMS) is vital for understanding brain-behavior links and treating neurological/psychiatric disorders.
  • Left dorsolateral prefrontal cortex (DLPFC) TMS is an FDA-approved treatment for major depressive disorder (MDD).
  • Variability in TMS response, often due to stimulation intensity, presents a significant clinical challenge.

Purpose of the Study:

  • To establish dose-response relationships for TMS in the DLPFC using concurrent TMS/fMRI.
  • To investigate how varying stimulation intensities affect brain activity.

Main Methods:

  • Fifteen subjects underwent concurrent TMS/fMRI at 80%, 90%, 100%, and 110% of their motor threshold.
  • Data collection included anatomical scans for neuronavigation and functional scans for dose-response mapping.
  • Generalized Linear Models (GLMs) were computed for individual subjects and group-level analyses at each intensity.

Main Results:

  • Group-level analysis indicated the strongest Blood-Oxygen-Level-Dependent (BOLD) response at 100% stimulation intensity.
  • Individual analyses revealed diverse dose-response patterns, including responses to subthreshold, suprathreshold, and atypical stimulation levels.
  • Significant inter-subject variability in DLPFC TMS response was observed.

Conclusions:

  • Individual motor thresholds may not directly predict DLPFC excitability, highlighting the need for personalized TMS protocols.
  • Concurrent TMS/fMRI shows promise for improving response rates in repetitive TMS (rTMS) applications.
  • Future research should explore implementing TMS/fMRI or cost-effective alternatives for optimizing clinical TMS dosing and targeting.