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Related Concept Videos

Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein...
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Updated: Jul 14, 2025

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
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Nodular (keloidal) scleroderma.

Natalia Gabriela Sanchez1, Natalia Rebollo Domínguez2, Eduwiges Martínez Luna3

  • 1Digital Pathology Laboratory, Instituto Tecnológico y de Estudios Superiores De Monterrey Campus Ciudad de México, Mexico.

Reumatologia Clinica
|October 7, 2023
PubMed
Summary

Keloidal or nodular scleroderma, a rare localized scleroderma variant, often appears in systemic sclerosis patients. This case highlights its presentation with characteristic dermal fibrosis.

Keywords:
EsclerodermiaEsclerodermia nodularEsclerodermia queloideaEsclerosis sistémicaKeloidal sclerodermaNodular sclerodermaSclerodermaSystemic sclerosis

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Area of Science:

  • Dermatology
  • Rheumatology
  • Pathology

Background:

  • Localized scleroderma (LS) encompasses several subtypes.
  • Systemic sclerosis (SSc) is a chronic autoimmune disease affecting connective tissues.
  • Keloidal or nodular scleroderma (NS) is a recognized, albeit uncommon, variant of LS.

Observation:

  • The patient presented with clinical features suggestive of keloidal or nodular scleroderma.
  • These features included raised, firm plaques or nodules.
  • Histopathological examination revealed extensive dermal fibrosis and hyalinized collagen bundles.

Findings:

  • The patient was diagnosed with systemic sclerosis (SSc).
  • Keloidal or nodular scleroderma (NS) was identified as a manifestation within the context of SSc.
  • The presentation aligns with the known association between NS and SSc, particularly limited or diffuse subtypes.

Implications:

  • This case underscores the importance of recognizing NS as a potential manifestation in SSc patients.
  • Understanding this association can aid in earlier diagnosis and management of SSc.
  • Further research may elucidate the specific mechanisms linking SSc and NS.