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Related Experiment Video

Updated: Jul 14, 2025

Simple and Computer-assisted Olfactory Testing for Mice
06:40

Simple and Computer-assisted Olfactory Testing for Mice

Published on: June 15, 2015

10.1K

Protocol for quantifying the odor detection threshold of mice.

Chloe Elise Johnson1, Ellie Williams1, Adam Dewan1

  • 1Department of Psychology, Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA.

STAR Protocols
|October 8, 2023
PubMed
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This study details a precise method for measuring mouse odor detection thresholds using a head-fixed operant conditioning system. This protocol allows for sensitive comparisons of olfactory perception across different odorants and experimental conditions.

Area of Science:

  • Neuroscience
  • Olfactory research
  • Behavioral science

Background:

  • Odor threshold measurements are crucial for comparing species sensitivity and determining stimulus concentrations.
  • Quantifying olfactory detection in animal models is essential for understanding sensory perception.

Purpose of the Study:

  • To present a detailed protocol for precisely quantifying the odor detection threshold in mice.
  • To enable comparisons of olfactory sensitivity across various odorants and experimental manipulations.

Main Methods:

  • Construction of a head-fixed operant conditioning behavioral rig.
  • Detailed description of training and testing procedures for odor detection.
  • Utilizing a precise protocol to measure olfactory sensitivity in mice.
Keywords:
BehaviorModel OrganismsNeuroscience

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Related Experiment Videos

Last Updated: Jul 14, 2025

Simple and Computer-assisted Olfactory Testing for Mice
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Simple and Computer-assisted Olfactory Testing for Mice

Published on: June 15, 2015

10.1K
Testing for Odor Discrimination and Habituation in Mice
06:41

Testing for Odor Discrimination and Habituation in Mice

Published on: May 5, 2015

17.9K
An Objective and Reproducible Test of Olfactory Learning and Discrimination in Mice
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An Objective and Reproducible Test of Olfactory Learning and Discrimination in Mice

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Main Results:

  • The protocol allows for precise quantification of odor detection thresholds in mice.
  • The method facilitates comparisons of sensitivity across different odorants.
  • Detection differences associated with genetic or pharmacological manipulations can be quantified.

Conclusions:

  • The described protocol offers a robust method for assessing mouse olfactory detection thresholds.
  • This approach is valuable for comparative olfactory studies and investigating factors influencing scent perception.
  • The protocol supports research into genetic and pharmacological effects on olfaction.