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Updated: Jul 14, 2025

Layer-by-layer Collagen Deposition in Microfluidic Devices for Microtissue Stabilization

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Degradation Therapy with Collagenase and Deoxycholate.

Louise McDonald¹, Lauren Hoffman², Anne Chapas²

¹Department of Dermatology, Ulster Hospital, Upper Newtownards Road, Dundonald, Belfast, Northern Ireland BT16 1RH, UK.

Facial Plastic Surgery Clinics of North America

|October 8, 2023

Summary

Deoxycholic acid offers non-surgical submental fat reduction, while collagenase aids in wound healing and scar management. Both substances leverage natural degradation properties for therapeutic benefits.

Keywords:

ATX-101 Collagenase Degradation therapy Deoxycholate Deoxycholic acid Kybella Non-invasive facial contouring Submental fat

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Area of Science:

Biochemistry
Dermatology
Plastic Surgery

Background:

Deoxycholic acid and collagenase are naturally occurring enzymes.
These enzymes possess degradation capabilities for adipose tissue and collagen, respectively.
Their properties have led to diverse therapeutic applications.

Purpose of the Study:

To discuss indications for deoxycholic acid, focusing on non-surgical submental fat reduction.
To review collagenase indications for wound healing, scarring, and adipose tissue modification.
To detail patient assessment, procedural techniques, risks, and clinical tips for deoxycholic acid use.

Main Methods:

Literature review of deoxycholic acid for submental fat reduction.
Review of collagenase mechanism of action and benefits.
Discussion of clinical applications, patient selection, and procedural considerations.

Main Results:

Deoxycholic acid is established for non-surgical reduction of submental fat.
Collagenase demonstrates benefits in wound healing, scarring, and adipose tissue modification.
Key clinical tips, risks, and pitfalls associated with deoxycholic acid are outlined.

Conclusions:

Deoxycholic acid and collagenase are valuable therapeutic agents for specific medical and aesthetic applications.
Understanding their mechanisms and proper application is crucial for optimal outcomes.
Further research may expand their therapeutic roles.