Microfocused Ultrasound With Visualization: A Systematic Review of Adverse Events and Risk of Subsequent Facelift...

Area of Science:

• Aesthetic Medicine
• Plastic Surgery
• Dermatology

Background:

• Concerns exist regarding noninvasive energy-based therapies like microfocused ultrasound with visualization (MFU-V) potentially causing facial fat loss.
• Unconfirmed reports suggest MFU-V may negatively impact subsequent rhytidectomy (facelift) procedures.

Purpose of the Study:

• To systematically review treatment-related adverse events (TRAEs) associated with MFU-V.
• To assess the impact of MFU-V on future facelift surgeries.

Main Methods:

• Systematic literature search of PubMed/MEDLINE using keywords: "MFU-V," "fat loss," "adverse events," "facelift."
• Searched the MAUDE database for Ulthera device reports.
• Extracted data from 19 articles (506 patients) and 106 MAUDE records.

Main Results:

• Most common TRAEs in literature were transient edema, erythema, and pain.
• Significant TRAEs were rare, with one case of subcutaneous atrophy reported.
• MAUDE data revealed higher frequencies of lipoatrophy, neurologic sequelae (nerve damage, ptosis), and scarring.
• One MAUDE report mentioned facelift compromise.

Conclusions:

• Scientific literature currently lacks robust evidence linking MFU-V to negative outcomes in subsequent facelifts.
• Anecdotal reports suggest potential risks, highlighting the need for peer-reviewed data.
• Further research is needed to understand MFU-V's long-term effects and risks associated with facial fat and surgical procedures.