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Updated: Jul 14, 2025

Resin-Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation
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Resin-Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation

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The interaction between NLRP1 and oxidized TRX1 involves a transient disulfide bond

Michael B Geeson, Jeffrey C Hsiao, Lydia P Tsamouri

    Biorxiv : the Preprint Server for Biology
    |October 9, 2023
    PubMed
    Summary

    The NLRP1 inflammasome receptor selectively binds oxidized thioredoxin-1 (TRX1) by forming a disulfide bond. This interaction reveals how NLRP1 senses cellular redox states to regulate innate immunity and pyroptosis.

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