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Updated: Jul 5, 2025

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The interaction between NLRP1 and oxidized TRX1 involves a transient disulfide bond

Michael B Geeson1, Jeffrey C Hsiao2, Lydia P Tsamouri2

  • 1Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Cell Chemical Biology
|January 12, 2024
PubMed
Summary

The NLRP1 inflammasome receptor binds oxidized thioredoxin-1 (TRX1) via a disulfide bond, revealing how the innate immune system senses cellular redox states.

Keywords:
AlphaFold-MultimerNLRP1disulfideinflammasomepyroptosisredoxthioredoxin

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