Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

678
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
678
Sympathetic Activation01:17

Sympathetic Activation

5.3K
The sympathetic division can influence tissues and organs by releasing norepinephrine at peripheral synapses and distributing epinephrine and norepinephrine through the bloodstream. In times of crisis or stress, sympathetic activation occurs, which is regulated by sympathetic centers in the hypothalamus. As a result, sympathetic activation prepares the body for physical exertion, rapid ATP production, and heightened alertness, allowing individuals to respond effectively to challenging or...
5.3K
Sympathetic Pathways: Sympathetic Chain Ganglia01:20

Sympathetic Pathways: Sympathetic Chain Ganglia

2.7K
The sympathetic chain ganglia, also known as the sympathetic trunk ganglia or paravertebral ganglia, are a series of ganglia located bilaterally on either side of the spinal column. These ganglia serve as relay stations for the sympathetic nervous system. Preganglionic neurons originating in the spinal cord project their axons to the sympathetic chain ganglia. Within the ganglia, these preganglionic fibers synapse with postganglionic neurons.The postganglionic neurons of the sympathetic trunk...
2.7K
Sympathetic Signaling01:32

Sympathetic Signaling

998
Sympathetic signaling, a vital part of the autonomic nervous system, plays a crucial role in mobilizing the body's resources in response to stress or emergencies. It involves the transmission of nerve impulses from sympathetic preganglionic fibers to postganglionic fibers. This results in the release of specific neurotransmitters and activation of adrenergic receptors.
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
998
Autonomic Nervous System01:22

Autonomic Nervous System

9.0K
The autonomic nervous system (ANS) is a critical component of the peripheral nervous system, primarily responsible for regulating involuntary bodily functions and maintaining homeostasis. It functions in tandem with the central nervous system (CNS) to seamlessly coordinate various physiological processes without the need for conscious control.
The ANS comprises two main divisions: the sympathetic and parasympathetic divisions. These divisions function antagonistically to maintain a dynamic...
9.0K
Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla01:28

Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla

1.3K
The sympathetic pathways of the collateral ganglia and adrenal medulla serve unique but interconnected roles in the sympathetic response.
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aging Disrupts L-type Ca<sup>2+</sup> Channel Organization and Function in Pacemaker Cells.

Circulation research·2026
Same author

Cholesterol, PtdIns(4,5)P<sub>2</sub>, and Actin Regulate BK Channel Nanoscale Organization.

bioRxiv : the preprint server for biology·2026
Same author

Functionally coupled ion channels begin co-assembling at the start of their synthesis.

eLife·2026
Same author

Impact of vascular density on pancreatic islet viability: a computational study.

Frontiers in physiology·2025
Same author

Functionally-Coupled Ion Channels Begin Co-assembling at the Start of Their Synthesis.

bioRxiv : the preprint server for biology·2025
Same author

Aging reduces the number and function of L-type calcium channels in the membrane of cardiac pacemaker cells.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Jul 14, 2025

Author Spotlight: Exploring Plasticity of Sympathetic Neurons
05:24

Author Spotlight: Exploring Plasticity of Sympathetic Neurons

Published on: July 5, 2024

2.3K

Sympathetic Motor Neuron Dysfunction is a Missing Link in Age-Associated Sympathetic Overactivity.

Lizbeth de la Cruz1, Derek Bui1, Claudia M Moreno1,2

  • 1Department of Physiology and Biophysics, University of Washington, Seattle, WA.

Biorxiv : the Preprint Server for Biology
|October 9, 2023
PubMed
Summary

Aging increases sympathetic nervous system activity by affecting peripheral motor neurons. Reduced M current in these neurons contributes to age-related hyperexcitability, highlighting the importance of peripheral mechanisms in aging.

More Related Videos

Surgical Technique for Superior Cervical Ganglionectomy in a Murine Model
07:30

Surgical Technique for Superior Cervical Ganglionectomy in a Murine Model

Published on: December 2, 2022

4.7K
Efficient Differentiation of Postganglionic Sympathetic Neurons using Human Pluripotent Stem Cells under Feeder-free and Chemically Defined Culture Conditions
10:24

Efficient Differentiation of Postganglionic Sympathetic Neurons using Human Pluripotent Stem Cells under Feeder-free and Chemically Defined Culture Conditions

Published on: May 24, 2020

14.9K

Related Experiment Videos

Last Updated: Jul 14, 2025

Author Spotlight: Exploring Plasticity of Sympathetic Neurons
05:24

Author Spotlight: Exploring Plasticity of Sympathetic Neurons

Published on: July 5, 2024

2.3K
Surgical Technique for Superior Cervical Ganglionectomy in a Murine Model
07:30

Surgical Technique for Superior Cervical Ganglionectomy in a Murine Model

Published on: December 2, 2022

4.7K
Efficient Differentiation of Postganglionic Sympathetic Neurons using Human Pluripotent Stem Cells under Feeder-free and Chemically Defined Culture Conditions
10:24

Efficient Differentiation of Postganglionic Sympathetic Neurons using Human Pluripotent Stem Cells under Feeder-free and Chemically Defined Culture Conditions

Published on: May 24, 2020

14.9K

Area of Science:

  • Neuroscience
  • Gerontology
  • Physiology

Background:

  • Sympathetic nervous system overactivity is a key feature of aging.
  • The underlying cellular mechanisms are not fully understood, with a focus on the central nervous system.
  • Aging's impact on peripheral sympathetic neurons is largely unexplored.

Purpose of the Study:

  • To investigate the effect of aging on the intrinsic properties and function of sympathetic motor neurons.
  • To identify cellular mechanisms contributing to age-related sympathetic overactivity in the peripheral nervous system.

Main Methods:

  • Electrophysiological recordings of neurons isolated from the superior cervical ganglia of mice at different ages (young, middle-aged, old).
  • Analysis of ion-channel activity to assess functional changes in sympathetic neurons.

Main Results:

  • Aging significantly alters the intrinsic electrophysiological properties of sympathetic motor neurons.
  • Spontaneous and evoked firing responses increase with age.
  • A reduction in M current is identified as a primary factor in age-related neuronal hyperexcitability.

Conclusions:

  • Aging directly impacts the function of peripheral sympathetic motor neurons.
  • Reduced M current contributes significantly to sympathetic overactivity in aged individuals.
  • Peripheral motor components are crucial to consider in the mechanisms of age-related sympathetic dysfunction.