The First Sign of Recurrent Angioimmunoblastic T-Cell Lymphoma: A Cutaneous Presentation

Area of Science:

• Oncology
• Dermatology
• Immunology

Background:

• Angioimmunoblastic T-cell lymphoma (AITL) is a peripheral T-cell lymphoma with diverse clinical presentations.
• Cutaneous manifestations of AITL are varied, including rashes, nodules, and erythroderma.

Observation:

• A 74-year-old male with a history of AITL presented with widespread erythematous macules and papules on the trunk and extremities.
• Histopathology revealed a lymphocytic infiltrate positive for PD-1, CD3, CD5, and BCL-6, with many EBV-positive cells.
• Bone marrow biopsy showed an atypical lymphoid infiltrate with EBV-positive cells and clonal TCR gene rearrangement.

Findings:

• The patient was diagnosed with recurrent AITL involving the skin.
• This case illustrates skin findings as the primary indicator of recurrent AITL.

Implications:

• This case underscores the importance of considering cutaneous manifestations in the diagnosis of recurrent AITL.
• Early recognition of skin findings can lead to timely diagnosis and management of AITL recurrence.