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Updated: Jul 14, 2025

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Calciphylaxis Secondary to Vitamin D Supplementation.

Joana Costa E Silva1, José N Ramos1

  • 1Plastic Reconstructive and Maxilofacial Surgery, Centro Hospitalar de Lisboa Ocidental, Lisbon, PRT.

Cureus
|October 9, 2023
PubMed
Summary

Non-uremic calciphylaxis (NUC), a rare skin disease, can occur in patients without kidney failure. This case suggests vitamin D supplementation may trigger NUC in susceptible individuals.

Keywords:
calcific uremic arteriolopathycalciphylaxisend-stage kidney diseasenon-uremic calciphylaxisvitamin d

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Area of Science:

  • Dermatology
  • Nephrology
  • Endocrinology

Background:

  • Calciphylaxis is a rare, severe skin condition characterized by purpuric and necrotic lesions.
  • It predominantly affects patients with end-stage renal disease but can occur in those with normal kidney function, termed non-uremic calciphylaxis (NUC).
  • The exact pathophysiology of calciphylaxis remains unclear, with various etiological factors proposed.

Observation:

  • This report details a case of non-uremic calciphylaxis.
  • The patient presented with symptoms of NUC despite having preserved renal function.
  • The onset of NUC in this patient was potentially linked to vitamin D supplementation.

Findings:

  • Vitamin D supplementation may be an underrecognized trigger for non-uremic calciphylaxis.
  • This case highlights the importance of considering metabolic factors in the differential diagnosis of calciphylaxis.
  • Further research is needed to elucidate the precise role of vitamin D in calciphylaxis pathogenesis.

Implications:

  • Clinicians should exercise caution when prescribing vitamin D supplements to patients at risk for calciphylaxis.
  • Identifying novel triggers like vitamin D supplementation could lead to improved diagnostic and therapeutic strategies for NUC.
  • This case underscores the need for a comprehensive etiological workup in non-uremic calciphylaxis.