Mathematical modeling of active contraction of the human cardiac myocyte: A review
Fisal Asiri1, Md Irfanul Haque Siddiqui2, Masood Ashraf Ali3
1Department of Mathematics, Taibah University, Medina, 42353, Saudi Arabia.
Background And Objective:
In this present research paper, a mathematical model has been developed to study myocyte contraction in the human cardiac muscle, using the Land model. Different parts of the human heart with a focus on the composition of the myocyte cells have been explored numerically to enabling us to determine the interaction of various parameters in the heart muscle. The main objective of the work is to direct the study of the Land model, which has been exploited to simulate the contraction of real human myocytes.
Methods:
Mathematical models has been developed based on the Hill model and Huxley model. Myocyte contraction for different scenarios, such as in isometric tension and isotonic tension have been studied.
Results:
It is found that increase in stretch, the peak active tension increases, in line with well-established length-dependent tension generation. Five parameters are selected: [Ca2+]T50, Tref, TRPN50, β0, and β1, which have been varied in between the range of -50%-100%, to examine the isometric effects of each parameter on the behavior of the tension developed in the intact myocyte cells, with the most sensitive parameter being [Ca2+]T50.
Conclusion:
In conclusion, it is found that the Land model provides a good platform for the analysis of the active contraction of the human cardiac myocyte.
Related Concept Videos
01:27Specialized Characteristics of Cardiac Muscles
Cardiac muscle cells are smaller than skeletal muscles, averaging 10–20 mm in diameter and 50–100 mm in length. However, they have large energy demands for continuous contraction and relaxation. This energy is almost exclusively derived from aerobic metabolism of energy...
01:25Smooth Muscle Contraction
The onset of contraction is triggered by an increase in calcium ions within the sarcoplasm, similar to the process in striated muscle. However, smooth muscles have a relatively smaller reservoir of the sarcoplasmic...
01:13Structure of Cardiac Muscles
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
01:16Actin and Myosin in Muscle Contraction
01:20Motor Unit Stimulation
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
01:10The Role of Actin and Myosin in Non-muscle Cells