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Comparative stability study and aggregate analysis of Bevacizumab marketed formulations using advanced analytical

Arpit Arunkumar Bana1, Nithin Sajeev2, Sabyasachi Halder2

  • 1Department of Pharmaceutical Analysis, Institute of Pharmacy, Nirma University, S. G. Highway, Ahmedabad, 382481, Gujarat, India.

Heliyon
|October 9, 2023
PubMed
Summary

This study characterized two bevacizumab (Bvz) biosimilars in India against the reference product Avastin®. Physicochemical analysis and stress testing revealed minor structural changes, indicating comparable quality and stability for biosimilar evaluation.

Keywords:
Aggregate analysisBevacizumabBiosimilarsIntact mass analysisStress study

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