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Primary cerebral angiosarcoma: a case report.

Hasan R Arafat¹, Muath Badawi², Mahmoud Ramahi³

¹Cancer Care Center, Augusta Victoria Hospital.

Annals of Medicine and Surgery (2012)

|October 9, 2023

Summary

This summary is machine-generated.

Epithelioid cerebral angiosarcoma, a rare brain tumor, was successfully treated in a patient with a history of breast cancer. The treatment involved surgery, chemoradiotherapy, and temozolomide, leading to tumor resolution and symptom relief.

Keywords:

angiosarcoma brain tumor case report concurrent chemoradiotherapy rare neoplasm

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Area of Science:

Neuro-oncology
Pathology
Medical imaging

Background:

Central nervous system (CNS) sarcomas are rare mesenchymal tumors.
Angiosarcomas represent an even rarer subtype with a poor prognosis and undefined therapeutic strategies.

Observation:

A 50-year-old female with a history of treated breast cancer presented with a tonic-clonic seizure.
Brain imaging revealed a cerebral space-occupying lesion, diagnosed as epithelioid cerebral angiosarcoma post-craniotomy and resection.
The patient's history of breast cancer necessitated excluding recurrence and metastasis.

Findings:

Concurrent chemoradiotherapy with temozolomide following surgical resection led to complete tumor resolution and symptom alleviation.
Radiological signs of blood product degradation were noted.
Immunohistochemistry is crucial for accurate diagnosis of cerebral angiosarcoma.

Implications:

Primary cerebral epithelioid angiosarcoma is a highly malignant tumor of unknown origin.
Surgical resection combined with concurrent chemoradiotherapy offers the optimal approach for managing cerebral angiosarcoma.
Cerebral angiosarcoma should be considered in the differential diagnosis of brain space-occupying lesions, particularly in patients with prior radiotherapy exposure.