Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
Internal Receptors01:31

Internal Receptors

Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
Internal Receptors01:31

Internal Receptors

Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
Spinal Cord: Information Processing01:10

Spinal Cord: Information Processing

The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
Regulation of Food Intake01:30

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Facile Fabrication Process for Handmade Fully Polymeric Neural Interfaces.

ACS applied bio materials·2026
Same author

Cutaneous Reactive Histiocytosis in Golden Retrievers: An Immunohistochemical Approach.

Veterinary dermatology·2026
Same author

Soft Depth Neural Probes Enable Chronic Recordings from the Rat Brainstem.

ACS applied bio materials·2026
Same author

Glucoerucin, Glucosinolate From Brassicaceae Vegetables, Improves the Metabolic Profile in a Murine Model of Diet-Induced Obesity.

Phytotherapy research : PTR·2026
Same author

Author Correction: Control of spatiotemporal activation of organ-specific fibers in the swine vagus nerve by intermittent interferential current stimulation.

Nature communications·2026
Same author

Decoupling simultaneous motor imagination and execution via orthogonal ECoG neural representations.

Nature communications·2026

Related Experiment Video

Updated: Jun 17, 2026

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
11:46

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

Published on: April 27, 2014

17.8K

Decoding bladder state from pudendal intraneural signals in pigs.

A Giannotti1, S Lo Vecchio1, S Musco2

  • 1The BioRobotics Institute and Department of Excellence in Robotics and AI, Scuola Superiore Sant'Anna, Pisa, Italy.

APL Bioengineering
|October 9, 2023
PubMed
Summary

This study introduces a new method for real-time bladder fullness decoding using pudendal nerve signals. This advances adaptive neuroprosthetics for treating lower urinary tract dysfunction.

More Related Videos

In Vitro Characterization of the Electrophysiological Properties of Colonic Afferent Fibers in Rats
08:19

In Vitro Characterization of the Electrophysiological Properties of Colonic Afferent Fibers in Rats

Published on: September 27, 2017

7.0K
Cystometric and External Urethral Sphincter Measurements in Awake Rats with Implanted Catheter and Electrodes Allowing for Repeated Measurements
10:07

Cystometric and External Urethral Sphincter Measurements in Awake Rats with Implanted Catheter and Electrodes Allowing for Repeated Measurements

Published on: January 30, 2018

16.0K

Related Experiment Videos

Last Updated: Jun 17, 2026

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
11:46

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

Published on: April 27, 2014

17.8K
In Vitro Characterization of the Electrophysiological Properties of Colonic Afferent Fibers in Rats
08:19

In Vitro Characterization of the Electrophysiological Properties of Colonic Afferent Fibers in Rats

Published on: September 27, 2017

7.0K
Cystometric and External Urethral Sphincter Measurements in Awake Rats with Implanted Catheter and Electrodes Allowing for Repeated Measurements
10:07

Cystometric and External Urethral Sphincter Measurements in Awake Rats with Implanted Catheter and Electrodes Allowing for Repeated Measurements

Published on: January 30, 2018

16.0K

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Urology

Background:

  • Current neuroprosthetics for lower urinary tract dysfunction use open-loop stimulation, leading to voiding issues.
  • Closed-loop systems offer better bladder capacity and voiding efficacy but lack real-time bladder state decoding.
  • Neural adaptation to continuous stimulation can cause dysfunction.

Purpose of the Study:

  • To develop a robust, real-time decoding strategy for bladder fullness states.
  • To enable adaptive closed-loop stimulation for neuroprosthetic devices.
  • To improve treatment for lower urinary tract dysfunction.

Main Methods:

  • Recorded intraneural pudendal nerve signals in anesthetized pigs.
  • Utilized the Random Forest classifier to decode three bladder-filling states (empty, full, micturition).
  • Validated the decoding algorithm's accuracy across multiple animals.

Main Results:

  • Achieved a mean balanced accuracy above 86.67% in decoding bladder fullness states.
  • Demonstrated successful real-time decoding of bladder states from neural signals.
  • Confirmed the algorithm's effectiveness across all five pigs.

Conclusions:

  • The developed decoding approach is a significant step towards adaptive closed-loop neuroprosthetics.
  • This method facilitates real-time pudendal nerve modulation for improved bladder control.
  • Paves the way for "assisted-as-needed" neuroprosthesis for lower urinary tract dysfunction.