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Engineering Metal-Phenolic Network Nanoparticles via Microfluidics.

Jingqu Chen1, Steve Spoljaric1, Alba Calatayud-Sanchez1,2,3

  • 1Department of Chemical Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.

ACS Applied Materials & Interfaces
|October 9, 2023
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Summary

Microfluidics enables precise engineering of metal-phenolic network nanoparticles (MPN NPs) for improved bioactive cargo delivery. This method offers greater control over nanoparticle size and enhanced protein loading compared to traditional bulk assembly.

Keywords:
bioactive materialsmetal−organic materialsmicrofluidicsnanoparticlespolyphenols

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Chemical Engineering

Background:

  • Metal-phenolic network nanoparticles (MPN NPs) are a versatile platform for incorporating and delivering bioactive cargo.
  • Microfluidics offers scalable synthesis and controlled reaction environments for materials engineering.

Purpose of the Study:

  • To leverage microfluidics for engineering the properties of bioactive MPN NPs.
  • To investigate the impact of microfluidics operating parameters and NP composition on MPN NP characteristics and performance.

Main Methods:

  • Assembly of MPN NPs using microfluidics by varying flow rate ratio, total flow rate, and temperature.
  • Characterization of MPN NP size, protein loading, and protein release behavior.
  • Comparison of microfluidics-assembled NPs with bulk-assembled NPs.

Main Results:

  • Microfluidics-assembled MPN NPs exhibit a broader tunable size range (∼40-330 nm) and higher protein loading (∼30%) than bulk-assembled NPs.
  • Both microfluidics and bulk-assembled NPs show pH-responsive protein release.
  • Microfluidics-assembled NPs demonstrate temperature-dependent protein release and tunable release profiles based on flow rate ratio.

Conclusions:

  • Microfluidics provides enhanced control over MPN NP properties, including size and protein loading.
  • The microfluidic approach advances the development and application of metal-organic materials for drug delivery and other uses.