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[Overacidified tissue and microcirculation (author's transl)]
Archiv Fur Geschwulstforschung
|January 1, 1978
Summary
Chemotherapy drug (CMT) combined with glucose infusion significantly reduces tumor tissue microcirculation. Adding hyperthermia further impairs blood flow, enhancing potential tumor damage by limiting essential nutrients.
Area of Science:
- Physiology
- Oncology
- Biomedical Engineering
Context:
- Reduced pH in tumor tissue inhibits blood microcirculation.
- Chemotherapy drug (CMT) administration affects tissue perfusion.
- Glucose infusion can alter metabolic processes in tumors.
Purpose:
- To discuss physiological fundamentals of microcirculation inhibition at low pH.
- To report on the design and results of a light probe array for in vivo microcirculation measurement.
- To quantify changes in microcirculation intensity in normal and tumor tissues under various conditions.
Summary:
- A light probe array was developed to measure in vivo microcirculation.
- CMT administration with glucose infusion reduced tumor microcirculation intensity from 80-66% to 8-4% within 300 minutes at 37°C.
- Combining CMT, glucose infusion, and hyperthermia (41-42°C) further reduced microcirculation to below 1%, severely limiting substrate supply to tumor cells.
Impact:
- Sustained reduction in microcirculation and substrate offer can lead to significant tumor tissue damage.
- This approach highlights a potential strategy for enhancing cancer treatment efficacy through combined therapies.
- Findings suggest that prolonged hyperthermia under conditions of severely limited microcirculation may be a potent anti-cancer modality.