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Updated: Jul 14, 2025

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
A Rare Case of Acute Calcium Pyrophosphate Deposition Disease Following Zoledronic Acid Infusion
Roxana Florica1, Marta B Sekh2
1Internal Medicine, Western Reserve Health Education, Warren, USA.
Abstract:
Calcium pyrophosphate deposition (CPPD) disease of the joints is a form of arthritis that can present in a severely debilitating form of pseudogout. Although mostly idiopathic, pseudogout has been reported following bisphosphonate therapy in only nine cases to date with a pathophysiology that remains unclear. We present the case of a 59-year-old postmenopausal woman who developed the rare onset of acute polyarticular CPPD disease following zoledronic acid infusion for the treatment of osteoporosis.
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