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Prognostic factors for multisystem inflammatory syndrome in children: A systematic review and meta-analysis

Daniel G Rayner1, David Gou2, Jason Z X Chen3

  • 1Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.

Acta Paediatrica (Oslo, Norway : 1992)
|October 10, 2023
PubMed

Insights

Younger age, male sex, and Black race are associated with increased risk of multisystem inflammatory syndrome in children (MIS-C) post-SARS-CoV-2 infection. Malignancy and respiratory disease may decrease MIS-C risk.

Area of Science:

  • Pediatric Infectious Diseases
  • Epidemiology
  • Systematic Reviews

Background:

  • Multisystem inflammatory syndrome in children (MIS-C) is a serious condition following SARS-CoV-2 infection.
  • Evidence on factors predicting MIS-C development is limited.
  • This study systematically reviews prognostic factors for MIS-C.

Approach:

  • Systematic search of five databases (Jan 2020-May 2023).
  • Inclusion of 12 observational studies (N=18,024) reporting multivariable regression models.
  • Meta-analysis of 13 prognostic factors using random-effects models and GRADE framework for evidence certainty.

Key Points:

  • Moderate certainty evidence suggests younger age (<12 years), male sex, and Black race increase MIS-C risk.
  • Moderate certainty evidence suggests malignancy and underlying respiratory disease decrease MIS-C risk.
  • Low certainty evidence indicates Asian race may increase MIS-C risk, while comorbidity may decrease it.

Conclusions:

  • Several prognostic factors for MIS-C post-SARS-CoV-2 infection have been identified.
  • Further research is needed to understand the underlying pathophysiology of MIS-C.
  • This systematic review and meta-analysis provides valuable insights into MIS-C risk stratification.
Abstract

Keywords:
COVID-19MIS-CPIMS-TSmultisystem inflammatory syndrome in childrenrisk factors

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