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Published on: December 1, 2023
549
Noncontact Respiratory Motion Detection in Anesthetized Rodents
Martin Donnelley1, Lina Lagerquist2, Patricia Cmielewski3
1Robinson Research Institute,; Adelaide Medical School, University of Adelaide, SA, 5001, Australia; Respiratory and Sleep Medicine, Women's and Children's Hospital, North Adelaide, SA, 5006, Australia.
Summary
The Panasonic HL-G108 sensor reliably detects rodent respiration during synchrotron X-ray imaging, outperforming the previous RC60 sensor. This advancement enables clearer images and reduced radiation exposure in live animal studies.
Area of Science:
- Biomedical engineering
- Physiology
- Medical imaging
Background:
- Live-animal X-ray imaging at synchrotron facilities presents unique challenges for physiological monitoring.
- Accurate respiratory detection is crucial for phase-gated imaging and monitoring respiratory rate in anesthetized rodents.
- Previous methods using the Philtec RC60 sensor had limitations in robustness and ease of use.
Purpose of the Study:
- To evaluate the Panasonic HL-G108 sensor for respiratory detection in live, anesthetized rodents during synchrotron X-ray imaging.
- To compare the performance of the HL-G108 sensor against the previously used Philtec RC60 sensor.
- To assess the HL-G108's effectiveness in smaller species like mice.
Main Methods:
- Direct comparison of Panasonic HL-G108 and Philtec RC60 sensors using an anesthetized rat.
- Assessment of sensor performance under infrared heat lamp conditions.
- Application of the HL-G108 for respiratory motion detection and gated image acquisition in rats and mice at the SPring-8 Synchrotron.
Main Results:
- The HL-G108 sensor demonstrated superior robustness and ease of configuration compared to the RC60 sensor.
- The HL-G108 produced a stable analog signal suitable for precise peak detection.
- Gated image acquisition using the HL-G108 significantly reduced motion artifacts and allowed for dose reduction via shuttering.
- The HL-G108 effectively detected respiration in mice, indicating its applicability to smaller species.
Conclusions:
- The Panasonic HL-G108 sensor is a more robust and user-friendly alternative for respiratory monitoring in small animal synchrotron imaging.
- Its reliable performance facilitates gated imaging, leading to improved image quality and reduced radiation dose.
- The HL-G108 is effective for respiratory detection in both rats and mice, broadening its utility in preclinical research.
