Clinico-Haematological Profile Of Chronic Lymphoproliferative Disorders In Patients Presenting With Lymphocytosis
Anila Rashid1, Syed Saqlain Ali Meerza2, Huma Mansoori3
1Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi,Pakistan.
JPMA. the Journal of the Pakistan Medical Association
|October 11, 2023
Summary
Most patients with lymphocytosis have lymphoproliferative disorders, primarily B-cell chronic lymphocytic leukemia. This study assessed their clinical and hematological profiles.
Area of Science:
- Hematology
- Oncology
- Clinical Pathology
Background:
- Lymphocytosis, an elevated lymphocyte count, can indicate various conditions.
- Chronic lymphoproliferative disorders (CLPDs) are a group of hematological malignancies.
Purpose of the Study:
- To determine the spectrum and clinico-hematological characteristics of CLPDs in patients presenting with lymphocytosis.
- To classify the types of CLPDs and associated patient demographics.
Main Methods:
- A retrospective cross-sectional study analyzed bone marrow aspirate and trephine data from January to November 2020.
- The World Health Organization criteria were used for diagnosis and classification of CLPDs.
- Data from 103 patients with lymphocytosis were analyzed.
Main Results:
- 82% of patients with lymphocytosis were diagnosed with CLPDs.
- All diagnosed CLPDs were B-cell types, with chronic lymphocytic leukemia (CLL) being the most prevalent (73%).
- The median age was 60 years, with a male predominance (3.6:1), and 73% experienced constitutional symptoms.
Conclusions:
- Lymphocytosis frequently indicates an underlying lymphoproliferative disorder.
- B-cell chronic lymphocytic leukemia is the most common CLPD identified in patients with lymphocytosis.
Keywords:
Lymphoproliferative disorder, Lymphocytosis, Chronic lymphocytic leukaemia, Bone
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