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3D printing-based full-scale human brain for diverse applications.

Weijian Hua1, Cheng Zhang1,2, Lily Raymond1

  • 1Department of Mechanical Engineering, University of Nevada Reno, Reno, Nevada, USA.

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Summary

This study introduces novel 3D printing methods for creating realistic human brain models and custom brain patches. These innovations aim to enhance surgical training and improve wound healing after brain tumor removal.

Keywords:
3D printingbrain patchfull-scale human brain modelsstimuli-responsive yield-stress bathsurgery trainingwound healing

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Surgical Innovation

Background:

  • Surgery is the primary treatment for brain tumors.
  • Current manufacturing limits the creation of realistic human brain models for surgical training.
  • Effective training tools are crucial for improving patient outcomes in neurosurgery.

Purpose of the Study:

  • To develop advanced 3D printing techniques for fabricating customized full-scale human brain models.
  • To create specialized brain patches for post-surgical wound healing.
  • To validate the efficacy of these 3D printing approaches in simulating surgical scenarios.

Main Methods:

  • Utilized stimuli-responsive yield-stress support baths for printing.
  • Developed an "peeling-boiled-eggs" inverse 3D printing strategy for brain models.
  • Employed sacrificial ink and photocurable materials for precise fabrication.

Main Results:

  • Successfully printed patient-specific brain patches that conform to wound dimensions.
  • Fabricated full-scale human brain models using the novel inverse 3D printing method.
  • Demonstrated the ability to mimic wound healing scenarios effectively.

Conclusions:

  • The proposed 3D printing approaches offer a viable solution for creating realistic brain models for surgical training.
  • Customized brain patches can be fabricated for improved post-operative wound management.
  • These advancements hold significant potential for neurosurgical education and patient care.