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Updated: Jul 13, 2025

Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation
Published on: September 24, 2021
Adenosine triphosphate-induced life-threatening arrhythmia.
Toru Miyoshi1, Takayuki Nagai1, Katsuji Inoue1
1Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan.
Adenosine triphosphate (ATP) can trigger dangerous ventricular fibrillation in patients with cardiac conditions, even though it is generally considered safe for treating wide QRS complex tachycardia. Careful monitoring during ATP administration is crucial, especially post-surgery.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Idiopathic dilated cardiomyopathy and recent mitral valve replacement are significant cardiac risk factors.
- Regular wide QRS complex tachycardia is a critical arrhythmia requiring prompt diagnosis and management.
Observation:
- A 68-year-old female patient experienced a transition from regular wide QRS complex tachycardia to ventricular fibrillation post-ATP administration.
- This event occurred five days after mitral valve replacement surgery.
Findings:
- Adenosine triphosphate (ATP), typically safe for tachycardia, precipitated a life-threatening ventricular fibrillation in this patient.
- Sympathetic overdrive secondary to ATP infusion is a potential mechanism for this adverse event.
Implications:
- Clinicians must exercise caution when administering ATP for wide QRS complex tachycardia, particularly in post-cardiac surgery patients.
- Enhanced vigilance and preparedness for managing severe arrhythmias are essential during ATP use in high-risk individuals.
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