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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Stress-Strain Diagram - Brittle Materials01:24

Stress-Strain Diagram - Brittle Materials

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Brittle materials, including glass, cast iron, and stone, exhibit unique characteristics. They fracture without considerable change in their elongation rate, indicating that their breaking and ultimate strength are equivalent. Such materials also show lower strain levels at the point of rupture. The failure in brittle materials predominantly results from normal stresses, as evidenced by the rupture created along a surface perpendicular to the applied load. These materials do not display...
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What is the Skeletal System?01:02

What is the Skeletal System?

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Overview
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Fractures: Bone Repair01:27

Fractures: Bone Repair

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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
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Spongy Bone01:09

Spongy Bone

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All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
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Classification of Bones01:18

Classification of Bones

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The bones of the human skeletal system are of varied shapes, sizes, and functions. They can be classified based on their shape and function into four major classes: long bones, short bones, flat bones, and irregular bones. Some classifications include a fifth type, the sesamoid bones, as a separate class, whereas others categorize them under short bones.
Long and Short Bones
The appendicular skeleton, particularly the upper and lower limbs, is primarily made of long and short bones. The...
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Related Experiment Video

Updated: Jul 13, 2025

Fragility Assessment of Bovine Cortical Bone Using Scratch Tests
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[Brittle bones].

Mathilde Fargeat1, Fanny Blondet2, Georgios E Papadakis3

  • 1Service de médecine interne générale, Hôpitaux universitaires de Genève, 1211 Genève 14.

Revue Medicale Suisse
|October 11, 2023
PubMed
Summary
This summary is machine-generated.

Long-term corticosteroid use, especially prednisone over 7.5 mg/d for 3+ months, can cause osteoporosis and vertebral fractures. Early fracture risk assessment is crucial for prevention.

Area of Science:

  • Endocrinology
  • Rheumatology
  • Geriatrics

Background:

  • Corticosteroids are widely used in clinical practice.
  • Long-term use necessitates consideration of side effects like osteoporosis.

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  • Osteoporosis risk increases with prednisone dosage >7.5 mg/d for >3 months.