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Updated: Jul 13, 2025

Crystallization of Membrane Proteins in Lipidic Mesophases
Published on: March 28, 2011
A Carbazole-1,8-Disulfonamide-Derived Cryptand Receptor for Anion Recognition
Junhong Li1, Lisha Yuan1, Qinrong Yang1
1National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, China.
Abstract:
A novel cryptand-like anion receptor 1 was synthesized in reasonable yield by a one-step condensation reaction. The UV-vis spectroscopic titrations indicated that cryptand 1 bound AcO- in preference to other monovalent anions (including its competing F- and H2PO4-) in CH3CN, generating a 1:1 binding complex with Ka = 51,000 M-1. Moreover, the crystal structures revealed that the acetate ion was encapsulated inside the cryptand's cavity in a 1:1 manner, through multiple N-H···O hydrogen bonds (although having two different crystal forms).
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