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Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
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Fetuin-A levels in association with calcific aortic valve disease: A meta-analysis

Muhammad Omar Larik1

  • 1Department of Medicine, Dow International Medical College, Karachi, Pakistan.

Atherosclerosis Plus
|October 12, 2023
PubMed

Insights

Lower fetuin-A levels are associated with calcific aortic valve disease (CAVD). This meta-analysis suggests fetuin-A may be a potential biomarker for CAVD, though further research is needed.

Area of Science:

  • Cardiovascular Medicine
  • Biomarker Discovery
  • Valvular Heart Disease Research

Background:

  • Calcific aortic valve disease (CAVD) is a prevalent valvular condition, particularly in aging populations.
  • Biomarkers are increasingly explored to aid CAVD diagnosis and severity assessment alongside imaging.
  • Fetuin-A is investigated for its potential role in CAVD.

Purpose of the Study:

  • To conduct a meta-analysis assessing the association between fetuin-A levels and the presence of CAVD.
  • To evaluate fetuin-A as a potential diagnostic biomarker for CAVD.

Main Methods:

  • Systematic literature search of PubMed and Cochrane databases up to April 2023.
  • Meta-analysis pooling data from studies including 3,280 CAVD patients and 7,505 controls (total 10,785 patients).
  • Risk of bias assessed using the Newcastle-Ottawa scale for cohort studies.

Main Results:

  • Significantly lower circulating fetuin-A levels were observed in patients with CAVD (SMD: -0.20; P=0.03).
  • No significant association was found between fetuin-A levels and CAVD in patients with co-existing kidney disease (SMD: 0.20; P=0.56).

Conclusions:

  • Initial findings suggest fetuin-A may be a potential biomarker for CAVD.
  • Further research is required to establish fetuin-A as a robust diagnostic biomarker for calcific aortic valve disease.
Abstract

Keywords:
Aortic sclerosisAortic stenosisCalcific aortic valve diseaseFetuin-A

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