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Sulforaphene Inhibits Periodontitis through Regulating Macrophage Polarization via Upregulating Dendritic Cell
Yilin Liao1, Qi Yan1, Tiange Cheng1
1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China.
Journal of Agricultural and Food Chemistry
|October 12, 2023
Summary
Sulforaphene (SFE) effectively treats periodontitis by shifting macrophage polarization from M1 to M2. This study identifies dendritic cell immunoreceptor (DCIR) as a key target for SFE
Area of Science:
- Immunology
- Oral Biology
- Pharmacology
Background:
- Periodontitis is a prevalent inflammatory disease causing tooth loss.
- Macrophage polarization is critical in periodontitis pathogenesis.
- Natural compounds are explored for modulating macrophage polarization.
Purpose of the Study:
- To investigate sulforaphene's (SFE) therapeutic potential in periodontitis.
- To determine SFE's effect on macrophage polarization.
- To identify SFE's molecular targets in periodontitis.
Main Methods:
- In vitro and in vivo experimental models of periodontitis.
- Macrophage polarization assays.
- Transcriptome sequencing to identify gene expression changes.
- Gene knockdown and overexpression studies for target validation.
Main Results:
- SFE inhibited M1 macrophage polarization and promoted M2 polarization.
- SFE suppressed periodontitis progression in experimental models.
- Transcriptome analysis revealed SFE upregulated dendritic cell immunoreceptor (DCIR, CLEC4A2).
- DCIR was confirmed as essential for SFE-mediated macrophage polarization.
Conclusions:
- Sulforaphene (SFE) demonstrates therapeutic efficacy against periodontitis by modulating macrophage polarization.
- SFE regulates macrophage polarization via upregulation of dendritic cell immunoreceptor (DCIR).
- DCIR represents a potential novel therapeutic target for periodontitis and related immune diseases.
