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PANoptosis: Mechanisms, biology, and role in disease

Xu Sun1, Yanpeng Yang2, Xiaona Meng1

  • 1Department of Integrated Chinese and Western Medicine, Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, China.

Immunological Reviews
|October 12, 2023
PubMed

Insights

PANoptosis is an inflammatory cell death process involving pyroptosis, apoptosis, and necroptosis. Understanding PANoptosis mechanisms is key for developing new disease therapies.

Area of Science:

  • Cellular biology
  • Immunology
  • Pathology

Background:

  • Cell death occurs via distinct subroutines.
  • PANoptosis is a unique inflammatory cell death modality integrating pyroptosis, apoptosis, and necroptosis.
  • PANoptosome complexes mediate PANoptosis through integrated cell death components.

Purpose of the Study:

  • To review the relationships between pyroptosis, apoptosis, and necroptosis.
  • To highlight key molecules in PANoptosome formation and PANoptosis activation.
  • To outline the roles of PANoptosis in diseases and its therapeutic potential.

Main Methods:

  • Literature review of existing studies on PANoptosis.
  • Analysis of molecular mechanisms underlying PANoptosome assembly and activation.
  • Examination of PANoptosis involvement in various disease contexts.

Main Results:

  • PANoptosis is triggered by diverse stimuli including infections and cancer.
  • Key molecules and their interactions in PANoptosome formation are identified.
  • PANoptosis plays multifaceted roles across the disease spectrum.

Conclusions:

  • Understanding PANoptosis mechanisms is crucial for identifying novel therapeutic targets.
  • Targeting PANoptosis offers potential therapeutic strategies for various diseases.
  • Further research is needed to address current concepts and issues in PANoptosis.
Keywords:
PANoptosisPANoptosomecancerimmunityinflammasome

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