Colon-targeted delivery of polyphenols: construction principles, targeting mechanisms and evaluation methods

Area of Science:

• Pharmacology
• Gastroenterology
• Drug Delivery Systems

Background:

• Polyphenols are recognized for their beneficial effects on colonic health.
• Polyphenols are susceptible to degradation in the gastrointestinal tract, necessitating protective measures.
• Effective delivery systems are crucial for enhancing polyphenol stability, colon-targeting, and bioavailability.

Purpose of the Study:

• To review research on colon-targeted controlled release systems for polyphenols.
• To discuss physiological factors influencing polyphenol delivery and absorption in the colon.
• To summarize various colon-targeted carriers, their release mechanisms, and assessment models.

Main Methods:

• Discussion of physiological factors affecting polyphenol dissolution, release, and absorption in the colon.
• Description of different types of colon-targeted carriers and their release mechanisms.
• Summary and critical analysis of existing colon-targeting assessment models.

Main Results:

• Identification of key physiological features impacting polyphenol delivery systems in the colon.
• Categorization of colon-targeted carriers based on their release strategies.
• Evaluation of the strengths and weaknesses of current colon-targeting assessment methods.

Conclusions:

• Colon-targeted delivery systems are essential for maximizing the therapeutic potential of polyphenols.
• Further research into advanced carriers and assessment models is needed.
• Strategic development of novel colon-targeted therapeutics can ensure polyphenol bioactivity in the colon.