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Updated: Jul 13, 2025

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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K-Homology Type Splicing Regulatory Protein: Mechanism of Action in Cancer and Immune Disorders

Jonathan D Leavenworth1, Nabiha Yusuf2, Quamarul Hassan1

  • 1Department of Oral and Maxillofacial Surgery, Institute of Oral Health Research, School of Dentistry, University of Alabama at Birmingham, Birmingham, AL, USA.

Critical Reviews in Eukaryotic Gene Expression
|October 12, 2023
PubMed

Insights

K homology-type splicing regulatory protein (KSRP) is crucial in cancer and immunology. This review details KSRP

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Immunology

Background:

  • K homology-type splicing regulatory protein (KSRP) is a key regulator in cellular processes.
  • It functions as a single-strand nucleic acid binding protein.

Purpose of the Study:

  • To provide a minireview of KSRP.
  • To describe its complex subcellular functions.

Main Methods:

  • Literature review of KSRP functions.
  • Analysis of KSRP's role in RNA metabolism and cellular processes.

Main Results:

  • KSRP regulates transcription and post-transcriptional processes.
  • It impacts RNA metabolism, miRNA biogenesis, stress granule formation, metastasis, and inflammation.

Conclusions:

  • KSRP is a multifaceted protein with significant roles in cancer and immunology.
  • Understanding KSRP's interactions is vital for determining its substrate fate and cellular outcomes.

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