Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Editorial: Transforming neurological recovery: the promise of regenerative neurorehabilitation.

Frontiers in neurology·2026

Same author

Astrocytic frataxin deficiency drives neurocognitive impairment in sickle cell mice.

PNAS nexus·2026

Same author

Heme-mediated Tau phosphorylation drives neurocognitive responses in sickle cell disease.

Blood. Red cells & iron·2026

Same author

Every hour counts: Venous thromboembolism prophylaxis after spinal trauma.

The journal of trauma and acute care surgery·2026

Same author

Design and characterization of in situ cell-penetrating multi-modal gadolinium-gold nanoparticles for MR and CT imaging.

Biomaterials·2026

Same author

SpIC3D imaging for spinal in situ contrast 3D visualization.

Cell reports methods·2025

Same journal

Segmentation of the parasagittal dura mater on multi-center 3D-FLAIR MRI.

NeuroImage·2026

Same journal

Spatial frequency channels implement a mental ruler in spatial vision.

NeuroImage·2026

Same journal

Exploring the Link Between Intravoxel Incoherent Motion Measured Brain Diffusivity During Wakefulness and Sleep Macrostructure in the Elderly.

NeuroImage·2026

Same journal

Closed-loop adaptation of transcranial magnetic stimulation intensity with electroencephalography feedback.

NeuroImage·2026

Same journal

Volumetric postmortem MRI of the medial temporal lobe in Alzheimer's disease and related disorders: methodological advances and implications for in vivo biomarker development.

NeuroImage·2026

Same journal

Neural responses to equity and inequity when receiving vicarious rewards for self and charity during adolescence.

NeuroImage·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 13, 2025

Horizontal Hippocampal Slices of the Mouse Brain

Horizontal Hippocampal Slices of the Mouse Brain

Published on: September 22, 2020

Mapping mesoscale connectivity within the human hippocampus.

Michel Modo¹, Katherine Sparling², Jacob Novotny²

¹Department of Radiology; Department of BioEngineering; McGowan Institute for Regenerative Medicine; Centre for Neuroscience University of Pittsburgh (CNUP); Centre for the Neural Basis of Cognition (CNBC).

|October 12, 2023

Summary

This summary is machine-generated.

This study used advanced MRI to map human hippocampus connections, revealing detailed pathways crucial for memory and emotion. Findings highlight unique anatomical organizations, particularly in the head region, offering new insights into brain function.

Keywords:

Connectivity Dentate Gyrus Hippocampus Mesoscale Mossy Fibers Perforant path Tractography Tri-synaptic circuit

More Related Videos

Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue

Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue

Published on: October 21, 2021

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Published on: March 8, 2024

Related Experiment Videos

Last Updated: Jul 13, 2025

Horizontal Hippocampal Slices of the Mouse Brain

Horizontal Hippocampal Slices of the Mouse Brain

Published on: September 22, 2020

Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue

Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue

Published on: October 21, 2021

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Published on: March 8, 2024

Area of Science:

Neuroscience
Neuroimaging
Human Anatomy

Background:

Hippocampal connectivity is vital for cognitive and emotional functions.
Understanding intrahippocampal circuitry requires detailed mapping of neural pathways.

Purpose of the Study:

To visualize and analyze the complete intrahippocampal connectivity network in the human brain.
To provide a systems-level view of the hippocampus using high-resolution diffusion MRI and tractography.

Main Methods:

Ex vivo mesoscale multi-shell diffusion MRI at 11.7T was performed on entire post-mortem human hippocampi.
Tractography techniques were employed to reconstruct neural pathways, including the perforant path, Schaffer collaterals, and mossy fibers.
Volumetric analysis and streamline cluster analysis were used to characterize anatomical organization and connectional properties.

Main Results:

The head region of the hippocampus exhibited a unique anatomical organization compared to the body and tail.
Tractography successfully visualized major pathways like the perforant path (tri-synaptic and temporoammonic) and Schaffer collaterals.
Distinct fiber angularity in the alveus enabled separation of afferent and efferent connections, and non-canonical translamellar connections were identified in the hilus.
Mossy fibers showed a lamellar organization and region-specific projections to the fimbria.

Conclusions:

Mesoscale tractography offers an unprecedented systems-level view of intrahippocampal connectivity.
The detailed mapping of hippocampal circuitry provides foundational data for understanding cognitive and emotional processing.
This study reveals novel insights into the complex anatomical organization and connectivity patterns within the human hippocampus.