Related Experiment Video
Updated: Jul 17, 2026
08:40
TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application
Published on: June 8, 2016
14.2K
Stimuli-Responsive Hydrogel Adhesives for Wound Closure and Tissue Regeneration
Hui Ren1,2, Zhen Zhang1, Xuesi Chen1,2
1CAS Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Macromolecular Bioscience
|October 12, 2023
Summary
Stimuli-responsive hydrogels offer advanced wound closure solutions, overcoming limitations of traditional sutures and staplers. This review highlights their design, applications, and future potential in tissue regeneration.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Traditional wound closure methods like sutures and staplers cause secondary tissue damage and require specialized expertise.
- Hydrogel adhesives present a noninvasive alternative for wound closure, tissue sealing, and regeneration due to their unique properties.
- Stimuli-responsive hydrogels offer tunable performance based on wound conditions, enhancing healing processes.
Purpose of the Study:
- To comprehensively review the advancements in stimuli-responsive hydrogel adhesives for tissue adhesion over the last decade.
- To explore the design principles and diverse applications of these advanced hydrogel materials.
- To discuss current challenges and future directions for stimuli-responsive hydrogel adhesives in wound management and tissue regeneration.
Main Methods:
- Review of recent literature focusing on stimuli-responsive hydrogel adhesives developed in the past 10 years.
- Categorization of hydrogels based on their response mechanisms: pH, temperature, photo, and enzyme sensitivity.
- Analysis of reported biomedical applications, including skin closure, hemostasis, and gastrointestinal sealing.
Main Results:
- Significant progress has been made in designing hydrogel adhesives responsive to various stimuli (pH, temperature, light, enzymes).
- These responsive hydrogels demonstrate great potential in diverse clinical applications, including skin closure and internal organ sealing.
- The tunable nature of stimuli-responsive hydrogels allows for optimized performance tailored to specific wound healing requirements.
Conclusions:
- Stimuli-responsive hydrogel adhesives represent a promising next-generation technology for wound closure and tissue regeneration.
- Further research into their design and application can overcome existing limitations and improve clinical outcomes.
- This review provides valuable insights for developing advanced hydrogel-based medical adhesives.
