Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

176
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
176
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K
Stimulants01:29

Stimulants

224
Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
224
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

12
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
12
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists01:23

Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

192
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
192
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

14
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
14

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Opposite Seasonal Variation in Nighttime and Morning Blood Pressure: A Longitudinal Study of Patients with Hypertension.

American journal of hypertension·2026
Same author

Low-intensity ultrasound induces angiogenesis by activating endothelial integrin signaling in male mice.

Physiological reports·2026
Same author

Antioxidant Probucol Reduces Mortality in Mice Exposed to Lethal Doses of Ionizing Radiation.

Radiation research·2026
Same author

Response to Letter to the Editor regarding "Relationship between radiation exposure and indicators of vascular resistance, arterial remodeling, and atherosclerosis".

The British journal of radiology·2026
Same author

Association between social isolation and increased arterial stiffness in older adults: a cross-sectional study.

Scientific reports·2026
Same author

Renal Artery Stenosis Detected Early Through Routine Health Checkups.

JACC. Case reports·2026
Same journal

Association between hypertension and incidence of cardiovascular disease events in young adults with type 2 diabetes: a nationwide cohort study.

Hypertension research : official journal of the Japanese Society of Hypertension·2026
Same journal

Association between hypertension phenotypes and aortic valve peak velocity: a potential tool for identifying white-coat hypertension.

Hypertension research : official journal of the Japanese Society of Hypertension·2026
Same journal

Randomized-controlled trial of sacubitril/valsartan and amlodipine combination in Japanese uncontrolled hypertensive patients (J-SAMIT).

Hypertension research : official journal of the Japanese Society of Hypertension·2026
Same journal

Pleiotropic effects of renal denervation beyond blood pressure reduction.

Hypertension research : official journal of the Japanese Society of Hypertension·2026
Same journal

Authors' reply to: "Prognostic enrichment or treatment target modification? Interpreting MRI-defined asymptomatic brain lesions in blood pressure research".

Hypertension research : official journal of the Japanese Society of Hypertension·2026
Same journal

Comment on: socioeconomic inequalities and trends in self-reported hypertension and antihypertensive medication use in Australia between 2009 and 2021: a nationwide population-based cohort study.

Hypertension research : official journal of the Japanese Society of Hypertension·2026
See all related articles

Related Experiment Video

Updated: Jul 13, 2025

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
07:46

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

43.7K

Smoking cessation and vascular endothelial function.

Yukihito Higashi1,2

  • 1Department of Regenerative Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan. yhigashi@hiroshima-u.ac.jp.

Hypertension Research : Official Journal of the Japanese Society of Hypertension
|October 12, 2023
PubMed
Summary
This summary is machine-generated.

Smoking impairs vascular endothelial function by increasing oxidative stress. While smoking cessation is expected to improve endothelial function, studies show inconsistent results, necessitating further research.

Keywords:
Endothelial functionOxidative stressRho-associated kinaseSmokingSmoking cessation

More Related Videos

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies
10:11

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies

Published on: October 22, 2014

19.2K
Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

9.9K

Related Experiment Videos

Last Updated: Jul 13, 2025

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
07:46

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

43.7K
Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies
10:11

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies

Published on: October 22, 2014

19.2K
Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

9.9K

Area of Science:

  • Cardiovascular Science
  • Pulmonology
  • Vascular Biology

Background:

  • Smoking is a primary risk factor for vascular endothelial dysfunction.
  • It is hypothesized that smoking reduces nitric oxide (NO) bioavailability via oxidative stress and inflammation.
  • Endothelial dysfunction is linked to atherosclerosis development.

Purpose of the Study:

  • To review the role of smoking in endothelial function.
  • To examine the effects of smoking cessation on vascular endothelial function.
  • To highlight the inconsistencies observed in studies on smoking cessation and endothelial health.

Main Methods:

  • This review synthesizes existing literature on smoking, endothelial function, and cessation.
  • It analyzes studies investigating the impact of quitting smoking on vascular health.
  • The review focuses on mechanisms like nitric oxide bioavailability, oxidative stress, and inflammation.

Main Results:

  • Smoking demonstrably impairs vascular endothelial function.
  • Smoking cessation does not consistently lead to improvements in endothelial function across all studies.
  • Existing research indicates variability in the outcomes of quitting smoking on vascular health.

Conclusions:

  • Smoking cessation's direct impact on improving endothelial function requires further investigation.
  • More research is needed to clarify the relationship between quitting smoking and endothelial recovery.
  • Understanding these nuances is crucial for developing effective interventions for smokers.