Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Altered autonomic balance drives the increase in cardiac output and arterial pressure during convulsive seizures in nonanesthetized sheep.

Epilepsia·2026
Same author

Intravenous megadose sodium ascorbate normalises elevations in intracranial pressure and restores pressor responsiveness to norepinephrine in ovine Gram-negative sepsis.

Scientific reports·2026
Same author

Early Persistent Kidney Injury and Long-Term Outcomes Following Lung Transplantation.

Clinical transplantation·2026
Same author

Effect of restrictive fluid balance in critically ill patients with acute kidney injury: a target trial emulation.

Critical care (London, England)·2026
Same author

Socioeconomic disadvantage and sepsis survival in Australian intensive care units: A retrospective cohort study.

Australian critical care : official journal of the Confederation of Australian Critical Care Nurses·2026
Same author

Visualizing and Quantifying Ventilation-Perfusion Mismatch by Electrical Impedance Tomography in Patients Undergoing Lung Transplantation: A Pilot Physiological Study.

Transplantation proceedings·2026

Related Experiment Video

Updated: Jul 13, 2025

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
11:56

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells

Published on: April 11, 2014

13.5K

Mega-dose sodium ascorbate: a pilot, single-dose, physiological effect, double-blind, randomized, controlled trial.

Fumitaka Yanase1,2, Sofia Spano1, Akinori Maeda1

  • 1Department of Intensive Care, Austin Hospital, Melbourne, VIC, Australia.

Critical Care (London, England)
|October 12, 2023
PubMed
Summary
This summary is machine-generated.

Mega-dose sodium ascorbate (NaAscorbate) did not significantly increase 24-hour urine output in septic shock patients. However, it improved organ function and reduced vasopressor needs, warranting further research.

Keywords:
SepsisSeptic shockSequential organ failure scoreSodium ascorbateVasopressorsVitamin C

More Related Videos

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
00:04

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

10.7K
Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
06:13

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

Published on: December 1, 2023

1.1K

Related Experiment Videos

Last Updated: Jul 13, 2025

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
11:56

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells

Published on: April 11, 2014

13.5K
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
00:04

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

10.7K
Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
06:13

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

Published on: December 1, 2023

1.1K

Area of Science:

  • Critical Care Medicine
  • Pharmacology
  • Biochemistry

Background:

  • Mega-dose sodium ascorbate (NaAscorbate) shows promise in experimental sepsis models.
  • Physiological effects of NaAscorbate in human septic shock patients remain largely unknown.

Purpose of the Study:

  • To investigate the effects of a single mega-dose of NaAscorbate on physiological parameters in patients with septic shock.
  • To evaluate the impact of NaAscorbate on urine output, vasopressor requirements, and organ function.

Main Methods:

  • A pilot, single-dose, double-blind, randomized controlled trial was conducted.
  • 30 patients with septic shock received either a mega-dose of NaAscorbate or placebo.
  • Primary outcome was total 24-hour urine output; secondary outcomes included vasopressor dose and SOFA score.

Main Results:

  • NaAscorbate did not significantly increase total 24-hour urine output (P=0.051).
  • Progressive cumulative urine output, vasopressor dose reduction, and Sequential Organ Failure Assessment (SOFA) score showed significant improvement over time with NaAscorbate (P<0.001 for all).
  • Increased sodium levels were observed with NaAscorbate; one case each of hypernatremia and hemolysis occurred.

Conclusions:

  • Mega-dose NaAscorbate did not significantly increase cumulative 24-hour urine output in septic shock.
  • NaAscorbate demonstrated a significant positive impact on urine output dynamics, vasopressor reduction, and SOFA scores over time.
  • Despite adverse events like hypernatremia, findings support further cautious investigation of NaAscorbate in septic shock.