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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...

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Related Experiment Video

Updated: Jun 5, 2026

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
09:54

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death

Published on: August 15, 2022

Early Persistent Kidney Injury and Long-Term Outcomes Following Lung Transplantation.

Kyosuke Dozono1, Akinori Maeda1,2, Yoshihisa Shimada3

  • 1Department of Emergency and Critical Care Medicine, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.

Clinical Transplantation
|June 4, 2026
PubMed
Summary
This summary is machine-generated.

Persistent kidney injury after lung transplantation predicts long-term adverse outcomes, even without acute kidney injury (AKI). Early creatinine trends, not just absolute levels, are key indicators for risk stratification.

Keywords:
acute kidney injurychronic kidney diseasecreatininelung transplantationpersistent kidney injurysubclinical kidney injury

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Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP
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Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP

Published on: February 14, 2022

Related Experiment Videos

Last Updated: Jun 5, 2026

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
09:54

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death

Published on: August 15, 2022

Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP
06:55

Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP

Published on: February 14, 2022

Area of Science:

  • Nephrology
  • Transplantation Medicine
  • Critical Care

Background:

  • Acute kidney injury (AKI) post-lung transplant impacts long-term outcomes.
  • Standard AKI diagnosis using absolute creatinine may be unreliable due to reduced muscle mass in transplant recipients.
  • This study explores early creatinine trajectories to identify persistent kidney injury.

Purpose of the Study:

  • To investigate persistent kidney injury, defined by early creatinine changes, in lung transplant recipients.
  • To assess the association between these kidney injury patterns and long-term outcomes, including chronic kidney disease (CKD) and major adverse kidney events (MAKE).
  • To evaluate the utility of the Day 7/Baseline Creatinine Ratio as an early prognostic marker.

Main Methods:

  • Retrospective analysis of adult lung transplant recipients.
  • Linear mixed-effects models to compare first-week creatinine trajectories based on long-term outcomes (2-year CKD, MAKE).
  • Multivariable logistic regression to assess the association between Day 7/Baseline Creatinine Ratio and adverse outcomes.

Main Results:

  • 26% of recipients developed postoperative AKI; 40-60% developed CKD post-transplant.
  • Patients with CKD showed a slower creatinine decline in the first week post-transplant (p < 0.001).
  • A higher Day 7/Baseline Creatinine Ratio independently predicted 2-year CKD (AOR: 4.54) and MAKE (AOR: 3.84).

Conclusions:

  • Early persistent kidney injury, identified through creatinine trajectories, is linked to adverse long-term outcomes post-lung transplant, irrespective of AKI diagnosis.
  • The Day 7/Baseline Creatinine Ratio shows promise as an early prognostic tool for risk stratification.
  • This ratio may aid in identifying high-risk patients for closer monitoring or intervention.