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Updated: Jul 13, 2025

Screening Traditional Chinese Medicine Compounds for Inhibiting UCHL3 Activity Based on Molecular Docking and Deubiquitinating Enzyme Probe Technology
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Screening Traditional Chinese Medicine Compounds for Inhibiting UCHL3 Activity Based on Molecular Docking and Deubiquitinating Enzyme Probe Technology

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Deubiquitinase OTUD3: a double-edged sword in immunity and disease

Qiao Xu1, Lan He2, Shubing Zhang1

  • 1Department of Cell Biology, School of Life Sciences, Central South University, Changsha, Hunan, China.

Frontiers in Cell and Developmental Biology
|October 13, 2023
PubMed

Insights

Ovarian tumor domain-containing protein 3 (OTUD3) is a deubiquitinating enzyme impacting protein homeostasis and disease. Understanding OTUD3 regulation offers therapeutic potential for cancer and inflammatory conditions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Deubiquitination is a critical post-translational modification regulating protein homeostasis.
  • Ovarian tumor domain-containing protein 3 (OTUD3) is a deubiquitinating enzyme involved in immunity and inflammation.
  • Dysregulation of these processes contributes to various diseases, including cancer and neurodegenerative disorders.

Purpose of the Study:

  • To explore the regulatory mechanisms of OTUD3 expression.
  • To elucidate the role of OTUD3 in disease pathogenesis.
  • To assess OTUD3 as a potential therapeutic target.

Main Methods:

  • Literature review of studies on OTUD3.
  • Analysis of transcriptional and post-translational regulation of OTUD3.
  • Examination of OTUD3's involvement in cancer and other diseases.

Main Results:

  • OTUD3 acts as a double-edged sword in cancer, influencing proliferation, metastasis, and metabolism.
  • OTUD3 expression is regulated by microRNAs (e.g., miR-520h, miR-32, miR101-3p) and post-translational modifications (acetylation, ubiquitination).
  • Aberrant OTUD3 expression is observed in various tumors.

Conclusions:

  • Understanding OTUD3 regulation provides insights into its function in immunity and disease.
  • OTUD3 presents a potential therapeutic target for diagnosing or treating diseases like cancer.
Keywords:
OTUD3cancerdeubiquitinasediseaseimmunity

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