Reproducibility of 3D thoracic aortic displacement from 3D cine balanced SSFP at 3 T without contrast enhancement

Aortic motion has direct impact on the mechanical stresses acting on the aorta. In aortic disease, increased stiffness of the aorta may lead to decreased aortic motion over time, which could be a predictor for aortic dissection or rupture. This study investigates the reproducibility of obtaining 3D displacement and diameter maps quantified using accelerated 3D cine MRI at 3 T.

A noncontrast-enhanced, free-breathing 3D cine sequence based on balanced SSFP and pseudo-spiral undersampling with high spatial isotropic resolution was developed (spatial/temporal resolution [1.6 mm]³ /67 ms). The thoracic aorta of 14 healthy volunteers was prospectively scanned three times at 3 T: twice on the same day and a third time 2 weeks later. Aortic displacement was calculated using iterative closest point nonrigid registration of manual segmentations of the 3D aorta at end-systole and mid-diastole. Interexamination and interobserver regional analysis of mean displacement for five regions of interest was performed using Bland-Altman analysis. Additionally, a complementary voxel-by-voxel analysis was done, allowing a more local inspection of the method.

No significant differences were found in mean and maximum displacement for any of the regions of interest for the interexamination and interobserver analysis. The maximum displacement measured in the lower half of the ascending aorta was 11.0 ± 3.4 mm (range: 3.0-17.5 mm) for the first scan. The smallest detectable change in mean displacement in the lower half of the ascending aorta was 3 mm.

Detailed 3D cine balanced SSFP at 3 T allows for reproducible quantification of systolic-diastolic mean aortic displacement within acceptable limits.