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Related Experiment Videos

Antibiotic stability in an implantable pump.

C R Perry, L L Ellington, A Becker

    Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
    |January 1, 1986
    PubMed
    Summary
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    Vancomycin degraded implantable drug pumps, while amikacin, netilmicin, tobramycin, gentamicin, clindamycin, and aztreonam showed stability and maintained biologic activity over three weeks.

    Area of Science:

    • Pharmacology
    • Biomaterials Science
    • Drug Delivery Systems

    Background:

    • Implantable drug pumps are crucial for sustained drug delivery.
    • Assessing antibiotic compatibility with pump materials is essential for therapeutic efficacy and safety.

    Purpose of the Study:

    • To evaluate the stability and compatibility of several antibiotics within an implantable drug pump system.
    • To determine if tested antibiotics affect pump integrity or lose biologic activity over time.

    Main Methods:

    • Seven antibiotics (vancomycin, amikacin, netilmicin, tobramycin, gentamicin, clindamycin, aztreonam) were placed in implantable drug pumps.
    • Pumps were incubated at 37°C for 3 weeks with daily sampling.
    • Pump integrity was assessed microscopically, and antibiotic biologic activity was quantified using bioassays.

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    Main Results:

    • Vancomycin was found to degrade the implantable drug pump materials.
    • Amikacin, netilmicin, tobramycin, gentamicin, clindamycin, and aztreonam demonstrated no adverse effects on pump integrity.
    • These six antibiotics maintained their biologic activity throughout the 3-week study period.

    Conclusions:

    • Vancomycin is not suitable for use in this specific implantable drug pump system due to material degradation.
    • Amikacin, netilmicin, tobramycin, gentamicin, clindamycin, and aztreonam are compatible with the tested implantable drug pumps and retain efficacy.