Related Experiment Video
Updated: Jul 13, 2025
06:09
Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis
Published on: July 18, 2017
8.1K
Nephrotoxicity caused by colistin use in ICU: a single centre experience
Isa Kilic1, Yavuz Ayar2, İlkay Ceylan3
1Department of Anesthesiology and Intensive Care, Ministry of Health, Bursa City Hospital , Bursa, Turkey. kilicisaicu@gmail.com.
BMC Nephrology
|October 13, 2023
Summary
The use of vasopressors is linked to acute kidney injury (AKI) in patients treated with colistin. This finding promotes safer colistin use in intensive care units for multidrug-resistant infections.
Area of Science:
- Nephrology
- Infectious Diseases
- Critical Care Medicine
Background:
- Colistin is crucial for treating multidrug-resistant Gram-negative bacterial infections.
- Colistin-induced acute kidney injury (AKI) is a significant concern in intensive care units.
- Identifying risk factors for colistin-induced AKI is essential for patient safety.
Purpose of the Study:
- To determine risk factors associated with colistin-induced AKI.
- To promote safer colistin administration in intensive care settings.
- To guide clinical practice for managing infections caused by multidrug-resistant pathogens.
Main Methods:
- Retrospective observational study of adult patients receiving intravenous colistin for at least 48 hours.
- Data collected from January 2020 to December 2020 in a tertiary care hospital's intensive care unit.
- AKI diagnosis and staging based on Kidney Disease Improving Global Outcome (KDIGO) criteria.
Main Results:
- 54 out of 148 patients (36%) developed AKI during colistin treatment.
- Univariate analysis identified age, comorbidity index, APACHE II score, colistin duration, baseline creatinine, vasopressor use, and vancomycin as significant risk factors.
- Multivariate analysis revealed vasopressor use as an independent predictor of AKI (OR: 3.14, p=0.06).
Conclusions:
- Vasopressor use is independently associated with AKI in critically ill patients undergoing colistin therapy.
- This finding highlights the need for careful monitoring of kidney function in patients receiving both colistin and vasopressors.
- Results support the development of strategies to mitigate AKI risk during colistin treatment.
Related Concept Videos
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
20
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
20
01:22Acute Kidney Injury I: Introduction
14
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
14
01:20Acute Kidney Injury V: Interprofessional Care
11
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
11
01:29Acute Kidney Injury III: Clinical Manifestations
13
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
13
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
15
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
15
01:28Cardiac Catheterization I: Pre-Procedure Overview
31
Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
31