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EuCARE-POSTCOVID Study: a multicentre cohort study on long-term post-COVID-19 manifestations
Benedetta Varisco1, Francesca Bai1, Sara De Benedittis2
1Department of Health Sciences, Clinic of Infectious Diseases, University of Milan, ASST Santi Paolo E Carlo, Via A Di Rudinì 8, 20142, Milan, Italy.
This study investigates the incidence and risk factors of post-COVID-19 condition, a persistent illness following COVID-19 infection. Understanding these predictors is crucial for managing long-term health outcomes in recovered patients.
Area of Science:
- Infectious Diseases
- Public Health
- Clinical Medicine
Background:
- Post-COVID-19 condition involves persistent symptoms like fatigue and cognitive difficulties after acute COVID-19.
- Prevalence varies widely, affecting 10-60% of patients, with poorly understood risk factors.
- The study is registered under NCT05531773.
Purpose of the Study:
- To assess the incidence and risk factors of post-COVID-19 condition.
- To evaluate the association between SARS-CoV-2 variants and post-COVID-19 risk.
- To examine long-term organ damage in relation to patient characteristics and viral factors.
Main Methods:
- A multicentre retrospective and prospective cohort study of COVID-19 patients (01/03/2020-01/02/2025).
- Includes a control group with non-COVID-19 respiratory infections.
- Follow-up at 2-3, 6-9, and 12-15 months with questionnaires and routine blood exams.
Main Results:
- The study aims to compare pandemic waves to understand post-COVID-19 predictors.
- Investigates gender association, particularly higher prevalence in females.
- Monitors symptom duration, evolution, vaccination status, reinfections, and new health issues.
Conclusions:
- This research will elucidate the incidence and predictors of post-COVID-19 condition.
- Biological samples will facilitate future studies on the mechanisms of post-COVID-19 sequelae.
- Findings will inform management strategies for long-term COVID-19 recovery.
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