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Vanadium levels in human kidney at autopsy.

C N Corder

    Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer
    |May 1, 1986
    PubMed
    Summary

    Human kidney tissue contains vanadium, with higher levels found in the medulla. Vanadium concentrations were not linked to age or sex but were elevated in kidneys from individuals with pulmonary pathology.

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    Area of Science:

    • Human physiology
    • Trace element analysis
    • Renal toxicology

    Background:

    • Vanadium is a trace element with potential biological effects.
    • Understanding vanadium distribution in human organs is crucial for toxicological assessment.
    • Kidney tissue is a potential site for trace element accumulation.

    Purpose of the Study:

    • To quantify vanadium levels in different regions of human kidneys.
    • To investigate the relationship between vanadium levels and demographic factors (age, sex).
    • To explore potential correlations between vanadium levels and cause of death, specifically pulmonary pathology.

    Main Methods:

    • Autopsy-obtained human kidney samples (n=24) were analyzed.
    • Atomic absorption spectroscopy was employed for vanadium quantification.
    • Kidney tissues were dissected into cortex, cortex-medulla, and medulla for regional analysis.

    Main Results:

    • Vanadium levels varied across kidney regions: medulla (1.97 mumoles/kg) > cortex (1.31 mumoles/kg) > cortex-medulla (1.27 mumoles/kg).
    • No significant correlation was observed between vanadium levels and donor age or sex.
    • Significantly elevated vanadium levels were detected in kidneys from individuals deceased due to pulmonary pathology.

    Conclusions:

    • Human kidney medulla exhibits higher vanadium accumulation compared to other regions.
    • Pulmonary pathology may be associated with increased vanadium levels in renal tissue.
    • Further research is warranted to elucidate the mechanisms behind vanadium accumulation and its clinical implications in the context of lung disease.

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