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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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The Potential of Hormonal Therapies for Treatment of Triple-Negative Breast Cancer

Melanie Kirkby1,2,3,4, Alyanna M Popatia1,2,3, Jessie R Lavoie1,4

  • 1Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada.

Cancers
|October 14, 2023
PubMed

Insights

Triple-negative breast cancer (TNBC) is aggressive and lacks targeted therapies. This review explores estrogen receptor beta, androgen receptor, and glucocorticoid receptor roles in TNBC, offering new therapeutic avenues.

Area of Science:

  • Oncology
  • Endocrinology
  • Molecular Biology

Background:

  • Triple-negative breast cancer (TNBC) is an aggressive subtype with limited treatment options due to the absence of estrogen receptor alpha, progesterone receptor, and HER2.
  • High heterogeneity in TNBC contributes to chemotherapy resistance and severe side effects, necessitating novel therapeutic strategies.

Purpose of the Study:

  • To review current findings on the roles of estrogen receptor beta (ERB), androgen receptor (AR), and glucocorticoid receptor (GR) in TNBC progression.
  • To discuss ongoing and completed clinical trials targeting these steroid hormone receptors in TNBC patients.

Main Methods:

  • Literature review of preclinical and clinical studies.
  • Analysis of data from clinical trials investigating ERB, AR, and GR as therapeutic targets in TNBC.

Main Results:

  • Emerging evidence suggests ERB, AR, and GR play significant roles in TNBC development and progression.
  • Clinical trials targeting these receptors show potential for improving outcomes in specific TNBC patient populations.

Conclusions:

  • Targeting ERB, AR, and GR represents a promising therapeutic strategy for TNBC.
  • Further research and clinical investigation are warranted to fully elucidate the therapeutic potential of these receptors in TNBC treatment.
Keywords:
androgen receptorenzalutamideestrogen receptor betaglucocorticoid receptorhormone therapymifepristonetamoxifentriple-negative breast cancer

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