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RvE1 Promotes Axin2+ Cell Regeneration and Reduces Bacterial Invasion.

Y-C Wu1,2,3, N Yu1,2, C A Rivas1,2

  • 1The Forsyth Institute, Cambridge, MA, USA.

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|October 14, 2023
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Summary
This summary is machine-generated.

Resolvin E1 (RvE1) promotes dental pulp regeneration by enhancing cell proliferation and differentiation. RvE1 also reduces inflammation and infection in endodontic diseases, offering a novel therapeutic approach.

Keywords:
apical periodontitisdental pulp stem cellsinfectionodontoblast(s)pulpitistissue repair

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Area of Science:

  • Endodontics
  • Regenerative Medicine
  • Immunology

Background:

  • Root canal therapy (RCT) for irreversible pulpitis has limitations, including increased root fracture risk and inability to achieve pulp regeneration.
  • Specialized proresolving mediators (SPMs), like resolvins, are known for their roles in inflammation resolution and tissue regeneration.
  • Resolvins have demonstrated potential in promoting dental pulp regeneration.

Purpose of the Study:

  • To investigate the cellular targets of Resolvin E1 (RvE1) in dental pulp regeneration.
  • To evaluate the impact of RvE1 on infected dental pulps.
  • To explore RvE1 as a potential therapeutic agent for endodontic diseases.

Main Methods:

  • Utilized an Axin2-tdTomato mouse model to study RvE1 effects on experimentally exposed pulps with and without infection.
  • Assessed RvE1's impact on cultured mouse dental pulp stem cells (mDPSCs) following lipopolysaccharide stimulation.
  • Evaluated RvE1's effects on inflammatory infiltration, bacterial invasion, and apical periodontitis in infected pulps.

Main Results:

  • RvE1 promoted Axin2-tdTomato+ cell expansion and odontoblastic differentiation in direct pulp capping models.
  • In mDPSCs, RvE1 enhanced proliferation, odontoblastic differentiation, and rescued LPS-impaired functions.
  • In infected pulps, RvE1 suppressed inflammation, reduced bacterial invasion, and prevented apical periodontitis, though proregenerative effects were limited.

Conclusions:

  • Topical RvE1 treatment promotes dental pulp regeneration by enhancing Axin2-expressing cell proliferation and differentiation.
  • RvE1 modulates inflammation resolution, reduces infection severity, and prevents apical periodontitis.
  • RvE1 presents a promising novel therapeutic for endodontic diseases.