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A new flow-based design for double-lumen needles
Radu Cimpeanu1, Alfonso A Castrejón-Pita2, Lee Nai Lim3
1Mathematics Institute, University of Warwick, Coventry, CV4 7AL, United Kingdom; Mathematical Institute, University of Oxford, Oxford, OX2 6GG, United Kingdom.
Journal of Biomechanics
|October 14, 2023
Summary
A new OxIVF needle improves oocyte retrieval in in vitro fertilization (IVF) by using hydrodynamics for gentle, effective fluid flow. This novel needle achieves up to 100% success, surpassing traditional methods and maximizing oocyte yield.
Area of Science:
- Reproductive Medicine
- Biomedical Engineering
- Fluid Dynamics
Background:
- Oocyte retrieval is critical for in vitro fertilization (IVF) success.
- Standard needles have limitations in efficiency and cost-effectiveness.
- Novel approaches are needed to enhance oocyte retrieval outcomes.
Purpose of the Study:
- To introduce and evaluate a novel hydrodynamics-based needle, the OxIVF needle, for improved oocyte retrieval.
- To compare the efficacy of the OxIVF needle against traditional double-lumen needles.
- To assess the impact of the OxIVF needle on oocyte stress and trajectory during retrieval.
Main Methods:
- Development of a two-dimensional digital twin of the follicular environment.
- Utilizing multi-phase flow direct numerical simulation to model fluid dynamics.
- Varying oocyte initial locations and measuring key fluid parameters like velocity and vorticity.
Main Results:
- The OxIVF needle demonstrated a superior success rate of up to 100%, compared to traditional needles (≤75%).
- Oocyte retrieval success with the OxIVF needle was independent of needle tip location.
- Simulations showed minimal stress on the oocyte, with a gentle flow guiding it towards extraction.
Conclusions:
- The OxIVF needle offers a significant advancement in oocyte retrieval technology.
- Its hydrodynamics-based design enhances efficiency and reduces oocyte stress.
- This innovation holds potential for improving IVF outcomes in both human and veterinary applications.
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