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Updated: Jul 13, 2025

Glycan Node Analysis: A Bottom-up Approach to Glycomics
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On a sugar high: Role of O-GlcNAcylation in cancer

Giang Le Minh1, Emily M Esquea1, Riley G Young1

  • 1Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.

The Journal of Biological Chemistry
|October 14, 2023
PubMed

Insights

O-GlcNAcylation, a protein modification regulated by O-GlcNAc transferase (OGT), is elevated in cancer. This review explores the latest findings on OGT and O-GlcNAc

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Aberrant glycosylation is increasingly recognized for its role in cancer progression.
  • O-GlcNAcylation, a post-translational modification, is gaining attention in cancer research.
  • O-GlcNAc transferase (OGT) catalyzes O-GlcNAcylation, linking nutrient availability to cancer signaling.

Purpose of the Study:

  • To review recent findings on the involvement of OGT and O-GlcNAc in cancer.
  • To highlight the significance of O-GlcNAcylation as a potential therapeutic target.

Main Methods:

  • Literature review of recent advancements in cancer research.
  • Analysis of studies investigating OGT and O-GlcNAc in cancer progression.

Main Results:

  • O-GlcNAcylation and OGT are significantly elevated in various cancers.
  • Both OGT and O-GlcNAc play crucial roles in regulating key cancer hallmarks.
  • O-GlcNAcylation influences cancer cell survival, proliferation, and progression.

Conclusions:

  • OGT and O-GlcNAc are critical regulators of cancer progression.
  • Targeting OGT and O-GlcNAcylation presents a promising therapeutic strategy for cancer.
Keywords:
O-GlcNAcOGTcancerhexosaminemetabolismmetastasis

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