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c-Jun as a one-way valve at the naive to primed interface

Dongwei Li1,2, Ling Luo3,4, Lin Guo3

  • 1Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, 190 Kaiyuan Dadao, Huangpu District, Guangzhou, 510799, China. lidongwei@gzhmu.edu.cn.

Cell & Bioscience
|October 14, 2023
PubMed
Summary

c-Jun protein acts as a one-way valve, stabilizing chromatin to maintain the primed cell state during early embryonic development. Loss of c-Jun impairs this process, facilitating easier reversion to the naïve cell state.

Keywords:
EpiSCsNaïve to primed transitionPrimed to naïve transitionc-Jun

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