Related Experiment Video
Updated: Jul 13, 2025

10:24
Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report
Published on: February 12, 2018
10.2K
Large orbital masses due to longstanding hydrogel retinal explants
Maria Mas-Castells1, David H Verity1, Geoffrey E Rose2
1Orbital Clinic, Moorfields Eye Hospital, London, EC1V 2PD, UK.
Eye (London, England)
|October 14, 2023
Summary
Late complications of hydrogel retinal explants can cause large orbital masses. These masses, presenting decades after surgery, are expanded explant material causing functional impairment.
Area of Science:
- Ophthalmology
- Ophthalmic Pathology
- Retinal Surgery Complications
Background:
- Hydrogel retinal explants were utilized in the 1980s for retinal detachment repair.
- Late complications can arise decades after the initial surgery.
Purpose of the Study:
- To characterize orbital masses as a late complication of hydrogel retinal explants.
- To describe the clinical and histopathological features of these masses.
Main Methods:
- Retrospective review of patients with orbital masses.
- Patients presented decades after retinal surgery with hydrogel explants.
Main Results:
- Two cases presented with huge orbital masses 25 and 28 years post-surgery.
- Masses were identified as expanded hydrogel explants with fibrous capsules.
- Histopathology revealed mild inflammation and calcification.
Conclusions:
- Expansile hydrogel explants can cause delayed, tumor-like parabulbar masses.
- These masses lead to orbital dysfunction and structural distortion.
- Surgical removal resulted in functional improvement.

