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Splanchnic vein thrombosis associated with SARS-CoV-2 infection: A VALDIG case-control study
Pierre Deltenre1,2,3, Audrey Payancé4, Laure Elkrief5
1CUB Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
JHEP Reports : Innovation in Hepatology
|October 16, 2023
Summary
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is linked to splanchnic vein thrombosis (SVT). Patients with SARS-CoV-2 and SVT may face a higher risk of intestinal infarction requiring surgery.
Area of Science:
- Vascular Medicine
- Infectious Diseases
- Gastroenterology
Background:
- The relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and splanchnic vein thrombosis (SVT) remains unclear.
- This study investigates the impact of SARS-CoV-2 on SVT presentation and outcomes.
Purpose of the Study:
- To assess the association between SARS-CoV-2 infection and recent SVT.
- To identify specific characteristics of SARS-CoV-2-associated SVT.
- To evaluate the prognosis of SVT in the context of SARS-CoV-2 infection.
Main Methods:
- Retrospective analysis of 27 patients with SARS-CoV-2 and SVT.
- Comparison with 494 patients with SVT prior to the SARS-CoV-2 pandemic.
- Data collected from 12 Vascular Liver Disease Group (VALDIG) centers.
Main Results:
- SARS-CoV-2-associated SVT commonly involved the portal vein.
- Patients with SARS-CoV-2 and SVT presented with more fever and respiratory symptoms and had lower lymphocyte counts.
- A higher rate of intestinal infarction requiring resection was observed in SARS-CoV-2-infected patients (11%) compared to controls (2.6%).
Conclusions:
- SARS-CoV-2 infection is associated with SVT.
- SVT in SARS-CoV-2 patients exhibits distinct clinical features, including respiratory symptoms and lymphopenia.
- There is an increased risk of intestinal infarction and subsequent resection in patients with SARS-CoV-2-associated SVT.
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