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Published on: July 26, 2024
Exploring the Potential of Natural Products as Antiparasitic Agents for Neglected Tropical Diseases
Dayanna Orosco1, Arturo René Mendoza1, Carlos Mario Meléndez1
1Grupo de Investigación en Química Orgánica y Biomedica, Programa de Química, Facultad de Ciencias Basicas, Universidad del Atlántico, A.A.1890, Barranquilla, Colombia.
Abstract:
Recent developments in the use of natural product-based molecules as antiparasitic agents for Malaria, leishmaniasis (LE), Chagas disease (CD), and Human African trypanosomiasis (HAT) are reviewed. The role of diverse plants in developing bioactive species is discussed in addition to analyzing the structural diversity of natural products as active agents and the diverse biological applications in CD, HAT, LE, and Malaria. This review focuses on medicinal chemistry, emphasizing the structural characteristics of natural molecules as bioactive agents against parasitic infections caused by Leishmania, Trypanosoma, and Plasmodium parasites.
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